CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 20 enrolled
Drug / intervention
Sevoflurane-propofoldrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04125121
NCT04125121N/ACompleted
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Neuroplasticity Induced by General Anaesthesia

Signe Sloth Madsen·interventional·Posted Oct 14, 2019·Updated Aug 20, 2021

In Brief

A clinical study evaluating Sevoflurane-propofol for Healthy Volunteers and 2 related conditions. Completed, enrolled 20 participants across 2 sites.

Detailed Summary

The aim of this study is to use magnetic resonance imaging to explore and compare possible de novo neuroplastic changes induced by the isolated effects of the hypnotic agents sevoflurane and propofol, respectively. In addition, to explore possible associations between neuroplastic changes and clinical and/or biochemical outcomes. It is a randomised, cross-over, single blinded clinical study. N = 30. Female:male ratio 1:1.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHealthy Volunteers, General Anaesthesia, Neuroplasticity
CountriesDenmark
Collaborators--

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedOct 14, 2019
Enrollment StartSep 26, 2019
Primary CompletionAug 13, 2021
TodayJul 2, 2026
Enrollment to primary: 1.9 yearsPosted 6.7 years ago

Interventions

Sevoflurane-propofoldrug

General anaesthesia with a maintenance phase of two hours duration with either sevoflurane or propofol.