CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 20 enrolled
Drug / intervention
Control Period +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04128215
NCT04128215N/ACompleted
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Sex Differences in Chronic and Acute Vascular Responses to Aerobic Exercise in Older Adults

University of Florida·interventional·Posted Oct 16, 2019·Updated Nov 14, 2024

In Brief

A clinical study evaluating Control Period and Exercise Period for Aging. Completed, enrolled 20 participants across 1 site.

Detailed Summary

A key early event in cardiovascular disease development is endothelial dysfunction, characterized by impaired flow-mediated dilation. Regular aerobic exercise ameliorates endothelial dysfunction in healthy older men, but the data in healthy postmenopausal women are inconsistent with many studies showing no effect. The primary objective of this study was to examine sex differences in acute and chronic endothelial responses to exercise training in older men vs. older postmenopausal women.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAging
CountriesUnited States
CollaboratorsNational Institute on Aging (NIA)

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedOct 16, 2019
Enrollment StartNov 22, 2019
Primary CompletionMay 31, 2023
TodayJul 2, 2026
Enrollment to primary: 3.5 yearsPosted 6.7 years ago

Interventions

Control Periodbehavioral

Participants completed an 8-week control period of normal lifestyle.

Exercise Periodbehavioral

Participants completed an 8-week exercise intervention period of remotely supervised home-based non-weight-bearing all-extremity high intensity interval training (NWA-HIIT). NWA-HIIT consisted of 4x4-min bouts at 90% of maximal heart rate (HRmax) interspersed by 3x3-min bouts at 70% of HRmax. A 10-min warm-up and 5-minute cool-down at 70% of HRmax were included.