CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 44 enrolled
Drug / intervention
CFZ533 +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04129528
NCT04129528Phase 2Completed

Investigator- and Subject-blinded, Randomized, Placebo-controlled Study to Evaluate Safety, Tolerability, Pharmacokinetics and Efficacy Trial of CFZ533 in Pediatric and Young Adult Subjects With New Onset Type 1 Diabetes (T1DM)

Novartis Pharmaceuticals·interventional·Posted Oct 16, 2019·Updated Apr 8, 2025

In Brief

A Phase 2 clinical trial evaluating CFZ533 and Placebo for Type 1 Diabetes Mellitus. Completed, enrolled 44 participants across 12 sites in 6 countries.

Detailed Summary

The study was a Phase 2, multicounty, multicenter, non-confirmatory, investigator- and subject masked, randomized, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics, and efficacy of CFZ533 on preservation of residual pancreatic β-cell function in new onset T1DM in pediatric and young adult subjects.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesBelgium, Germany, Italy, Slovenia, Spain, United Kingdom
Collaborators--

Timeline

Phase 2CompletedFinished
2020202120222023202420252026
First PostedOct 16, 2019
Enrollment StartNov 8, 2019
Primary CompletionJan 15, 2024
Study CompletionJun 4, 2024
TodayJul 2, 2026
Enrollment to primary: 4.2 yearsPosted 6.7 years ago

Interventions

CFZ533drug

First dose is administered via intravenous infusion, subsequent doses are administered subcutaneously.

Placeboother

Placebo for active drug