CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 77 enrolled
Drug / intervention
slow-wave disruptionbehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04150718
NCT04150718N/ACompleted
CompareCT.gov

Investigating the Role of Slow-wave Activity as a Marker of Impaired Plasticity in Major Depressive Disorder

University of Pennsylvania·interventional·Posted Nov 5, 2019·Updated Dec 27, 2024

In Brief

A clinical study evaluating slow-wave disruption for Depression. Completed, enrolled 77 participants across 1 site.

Detailed Summary

The hypothesis underlying this proposal is that deficits of synaptic plasticity underlie the slow-wave activity (SWA) abnormalities observed n major depressive disorder (MDD), and that manipulating SWA may serve to circumvent these deficits by facilitating an increase in synaptic strength via the inhibition of synaptic down-scaling, thereby improving plasticity and mood.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDepression
CountriesUnited States
CollaboratorsNational Institute of Mental Health (NIMH)

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedNov 5, 2019
Enrollment StartMar 4, 2020
Primary CompletionMar 31, 2023
Study CompletionJul 1, 2024
TodayJul 2, 2026
Enrollment to primary: 3.1 yearsPosted 6.7 years ago

Interventions

slow-wave disruptionbehavioral

A tone will be played through a speaker mounted over the bed that disrupts subjects while they are in slow-wave sleep. The tone will not be loud enough to wake up.