CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 44 enrolled
Drug / intervention
Fluid resuscitation and furosemide administration (bolus and continuous) with central venous pressure target 8 - 10 mmHg +1 moreprocedure
Likely dose
Not stated in record
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Search/NCT04156451
NCT04156451N/ACompleted
CompareCT.gov

Effectiveness of Fluid Deresuscitation With Central Venous Pressure Target 0-4 mmHg on Capillary Perfusion Density, Acute Kidney Injury Stage, Cardiac Index, and the Intensive Care Unit Length of Stay in Septic Shock Patients After Resuscitation

Indonesia University·interventional·Posted Nov 7, 2019·Updated May 2, 2025

In Brief

A clinical study evaluating Fluid resuscitation and furosemide administration (bolus and continuous) with central venous pressure target 8 - 10 mmHg and Fluid deresuscitation and furosemide administration (bolus and continuous) with central venous pressure target 0 - 4 mmHg for Septic Shock. Completed, enrolled 44 participants across 1 site.

Detailed Summary

A scientific research to prove the safety and effectiveness of TVS 0 - 4 mmHg as a target of resuscitation using furosemide, to improve Perfused Vessel Density (PVD) \> 25 mm / mm2, AKI stage (based on KDIGO criteria), CI \> 2.5 cc / min / m2 , prevent the incidence of intubation, reduce the duration of ventilator use \<120 hours and reduce the length of ICU stay in patients with septic shock after resuscitation

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsSeptic Shock
CountriesIndonesia
Collaborators--

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedNov 7, 2019
Enrollment StartNov 14, 2019
Primary CompletionSep 30, 2020
Study CompletionNov 30, 2020
TodayJul 2, 2026
Enrollment to primary: 11 monthsPosted 6.7 years ago

Interventions

Fluid resuscitation and furosemide administration (bolus and continuous) with central venous pressure target 8 - 10 mmHgprocedure

Crystalloid loading or furosemide administration with the CVP target 8-10 mmHg is reached in septic shock patients

Fluid deresuscitation and furosemide administration (bolus and continuous) with central venous pressure target 0 - 4 mmHgprocedure

active fluid removal with furosemide bolus and continuous or crystalloid loading until the CVP target 0-4 mmHg is reached in septic shock patients