CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 161 enrolled
Drug / intervention
Continue PD-1/PD-L1 Inhibitors treatment +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04157985
NCT04157985Phase 3Completed

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

Dan Zandberg·interventional·Posted Nov 8, 2019·Updated Dec 11, 2025

In Brief

A Phase 3 clinical trial evaluating Continue PD-1/PD-L1 Inhibitors treatment and Discontinue PD-1/PD-L1-1 inhibitor for Advanced Solid Tumors and 12 related conditions. Completed, enrolled 161 participants across 1 site.

Detailed Summary

Based on the overwhelming positive response to this survey and the large number of patients being treated with PD-1/PD-L1 therapy in the UPMC system, the investigators are proposing a trial that will randomize patients who have disease stability to stop treatment at 1 year or continue treatment until disease progression. The investigators anticipate that the results of this study will answer questions regarding the optimal duration of treatment. therapy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 3CompletedFinished
2020202120222023202420252026
First PostedNov 8, 2019
Enrollment StartNov 15, 2019
Primary CompletionOct 14, 2025
Study CompletionNov 7, 2025
TodayJul 2, 2026
Enrollment to primary: 5.9 yearsPosted 6.6 years ago

Interventions

Continue PD-1/PD-L1 Inhibitors treatmentdrug

Continued treatment with PD-1/PD-L1-1 inhibitor

Discontinue PD-1/PD-L1-1 inhibitorother

Discontinued treatment with PD-1/PD-L1-1 inhibitor