CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 25 enrolled
Drug / intervention
Targeted Transcranial Direct Current Stimulation +3 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04166513
NCT04166513N/ACompleted

Effects of tDCS in Language Recovery and Reorganization in Chronic Aphasia

Medical College of Wisconsin·interventional·Posted Nov 18, 2019·Updated Oct 3, 2025

In Brief

A clinical study evaluating Targeted Transcranial Direct Current Stimulation, Active Control Transcranial Direct Current Stimulation, and 2 other interventions for Stroke and Aphasia. Completed, enrolled 25 participants across 1 site.

Detailed Summary

This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsStroke, Aphasia
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedNov 18, 2019
Enrollment StartDec 13, 2019
Primary CompletionJul 1, 2024
TodayJul 2, 2026
Enrollment to primary: 4.5 yearsPosted 6.6 years ago

Interventions

Targeted Transcranial Direct Current Stimulationdevice

High-Definition-tDCS will be delivered via a battery-driven constant direct current stimulator (Soterix) using a 4x1 montage (1 central anodal electrode and 4 cathodal electrodes) arranged in a HD-cap. The current is turned on and increased in a ramplike fashion over approximately 30 seconds until reaching a strength of no more than 2mA, with a current density equal to 0.08mA/cm2. Stimulation will be maintained no longer than 20 minutes, and stimulation will be applied to the targeted region.

Active Control Transcranial Direct Current Stimulationdevice

High-Definition-tDCS will be delivered via a battery-driven constant direct current stimulator (Soterix) using a 4x1 montage (1 central anodal electrode and 4 cathodal electrodes) arranged in a HD-cap. The current is turned on and increased in a ramplike fashion over approximately 30 seconds until reaching a strength of no more than 2mA, with a current density equal to 0.08mA/cm2. Stimulation will be maintained no longer than 20 minutes, and stimulation will be applied to the active control region.

Phonologic-Focused Speech Therapybehavioral

Participants are asked to generate or choose from a list phonologic information about a target picture.

Semantic-Focused Speech Therapybehavioral

Participants who have difficulty retrieving an object name are given hierarchical clues or asked questions about the objects function as a way of activating the semantic network for that object, leading to eventual retrieval of the target word.