At a glance
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A Randomized, Double-blind, Placebo-controlled Multicenter Trial on the Efficacy of Varenicline and Bupropion in Combination and Alone, for Treatment of Alcohol Use Disorder
In Brief
A Phase 2 clinical trial evaluating Varenicline Tartrate 1 mg b.i.d, Bupropion Hydrochloride 150 mg b.i.d, and 2 other interventions for Alcohol Use Disorder and 2 related conditions. Completed, enrolled 388 participants across 4 sites.
Detailed Summary
The COMB study is a randomized double-blind placebo-controlled multicenter trial in Sweden on the efficacy of varenicline and bupropion, in combination and alone, for treatment of alcohol use disorder (AUD). Study design overview: A 13-weeks (91 days) multicenter clinical trial with four parallel groups. 95 subjects per treatment arm will be randomized into the study. 380 subjects with AUD will be randomized in total.
Study Details
Timeline
Interventions
Capsules for oral use
Capsules for oral use
Capsules for oral use
Capsules for oral use