At a glance
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PSG in Valproate-induced Nocturnal Enuresis in Children
In Brief
An observational study evaluating Clinical, EEG and laboratory assessment at presentation and Valproate for Epilepsy and Nocturnal Enuresis. Completed, enrolled 260 participants across 1 site.
Detailed Summary
Our study, retrospectively evaluate the characteristics of and the risk factors for the occurrence of nocturnal enuresis in epileptic children kept on valproate monotherapy. Epileptic children with the age ranged 5 up to 15 years who were started and kept up on valproate monotherapy. In this study, a child determined to have nocturnal enuresis based on the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, fourth edition: "an involuntary voiding of urine during sleep, with a severity of at least twice a week, in children aged 5 years or older, in the absence of congenital or acquired defects of the nervous system."
Study Details
Timeline
Interventions
* The patients' history, clinical, demographic, and laboratory data were acquired. * The following tests and imaging studies are routinely done for epilepsy patients receiving valproate treatment and developed nocturnal enuresis, blood urea nitrogen (BUN), serum creatinine (Cr), urinary pH (before and after valproate therapy beginning and at enuresis onset), serum levels and therapeutic doses of valproate. * Urinary tract ultrasonography (with full and void bladder). * CT brain and EEG.
valproate monotherapy