At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Return of Genomic Results and Aggregate Penetrance in Population-Based Cohorts
In Brief
A clinical study evaluating Genomic Sequencing for Seemingly Healthy and Genetic Predisposition to Disease. Completed, enrolled 48 participants across 2 sites.
Detailed Summary
The PopSeq Project is a prospective cohort study that will develop and implement a genomic return of results (gRoR) process in the Framingham Heart Study (FHS) and Jackson Heart Study (JHS) cohorts and explore associated medical, behavioral, and economic outcomes. The study will interpret the genomic sequences of JHS/FHS participants previously sequenced by TOPMed who have consented to genomic return of results and/or genetic testing. We will develop and apply new methods for scalable screening/ classification of genomic variants and will explore genomic penetrance by phenotyping a subset of participants in the FHS and JHS.
Study Details
Timeline
Interventions
Whole Genome Sequencing and reporting of actionable genomic results for genes included on the ACMG secondary findings list.