CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 18 enrolled
Drug / intervention
Dexmedetomidine +7 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04206059
NCT04206059N/ACompleted
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Closed Loop Acoustic Stimulation During Sedation With Dexmedetomidine

Washington University School of Medicine·interventional·Posted Dec 20, 2019·Updated May 1, 2026

In Brief

A clinical study evaluating MRI, Quantitative Sensory Testing (QST), and 6 other interventions for Sleep and Sedation Complication. Completed, enrolled 18 participants across 1 site.

Detailed Summary

Prospective within-subject study of dexmedetomidine sedation paired with CLAS conditions in repeated blocks. Intervention will consist of CLAS in-phase with EEG slow waves. Anti-phase stimulation will serve as an active control while sham stimulation will serve as a passive control.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsSleep, Sedation Complication
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedDec 20, 2019
Enrollment StartJan 20, 2021
Primary CompletionJun 1, 2022
Study CompletionJul 1, 2023
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 6.5 years ago

Interventions

MRIradiation

A non-contrast brain MRI will be acquired for localizing EEG slow waves

Quantitative Sensory Testing (QST)other

Quantitative sensory testing (QST) using increasing ramp thermal stimulation (32-52 ºC) will be delivered to compare arousal thresholds between conditions.

Home sleep studyother

Unattended home sleep studies will be conducted on the night preceding sedation and on the night following sedation to assess changes in slow wave homeostasis.

Acoustic stimulation (65 decibels or db) up-slope of EEG with QSTother

Acoustic stimulation (65 db) synchronized in-phase with the up-slope of EEG slow waves

Acoustic stimulation (65db) down-slope of EEG with QSTother

65 dB acoustic stimulation synchronized with the down-slope of the EEG slow waves (anti-phase)

0 db with QSTother

sham stimulation (0 dB volume)

Dexmedetomidinedrug

All participants will receive dexmedetomidine with sedation titrated step-wise to 2, 3 or 4 ng/ml

Breathe-Squeeze Taskother

All participants will be asked to perform the breathe-squeeze task throughout the experiment. This will allow us to determine loss and return of responsiveness.