CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 160 enrolled
Drug / intervention
aldafermin +1 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04210245
NCT04210245Phase 2Completed

Evaluation of Efficacy, Safety and Tolerability of NGM282 (Aldafermin) in a Phase 2b, Randomized, Double-blind, Placebo-controlled, Multi-center Study in Subjects With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (ALPINE 4)

NGM Biopharmaceuticals, Inc·interventional·Posted Dec 24, 2019·Updated Mar 26, 2025

In Brief

A Phase 2 clinical trial evaluating aldafermin and Placebo for Compensated Cirrhosis and Nonalcoholic Steatohepatitis. Completed, enrolled 160 participants across 49 sites in 9 countries.

Detailed Summary

A multi-center evaluation of aldafermin in a randomized, double-blind, placebo-controlled study in subjects with compensated cirrhosis.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustralia, Belgium, France, Germany, Hong Kong, Poland, Puerto Rico, United Kingdom, United States
Collaborators--

Timeline

Phase 2CompletedFinished
2020202120222023202420252026
First PostedDec 24, 2019
Enrollment StartMar 23, 2020
Primary CompletionJan 4, 2023
Study CompletionFeb 23, 2023
TodayJul 2, 2026
Enrollment to primary: 2.8 yearsPosted 6.5 years ago

Interventions

aldaferminbiological

aldafermin

Placeboother

Placebo for aldafermin