At a glance
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Graft Inflow Modulation for Portal Hyper-perfusion in Live Donor Liver Transplantation: a Randomized Pilot Study
In Brief
A clinical study evaluating Splenic artery ligation and No intervention for Cirrhosis, Liver. Completed, enrolled 75 participants across 1 site.
Detailed Summary
In this study, the investigators aim to prove that performing graft inflow modulation (GIM) in liver with portal hyper-perfusion is beneficial for early graft function postoperatively. Grafts at risk for portal hyper-perfusion will be identified by doing an intraoperative Doppler after reperfusion. In group A, the investigators will take 21 liver transplant recipients after reperfusion, randomly allocated, who will undergo intraoperative graft inflow modulation by splenic artery ligation. In group B, the investigators will be analyzing another randomly allocated 21 patients, who will not undergo any graft inflow modulation. The investigators will be analyzing trend of LFT's (liver function tests) after surgery, time for normalization of bilirubin, INR (international normalised ratio) and decrease in ascites, morbidity, mortality, ICU (intensive care unit) and total hospital stay.
Study Details
Timeline
Interventions
Splenic artery will be ligated just after takeoff from coeliac trunk at the level of body of pancreas
Splenic artery is not ligated despite the presence of portal hyperperfusion