CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 230 enrolled
Drug / intervention
selective hepatic vascular exclusion +1 moreprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04257240
NCT04257240N/ACompleted
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Does Vascular Occlusion in Liver Resections Predispose to Recurrence of Malignancy in the Liver Remnant Due to Ischemia/Reperfusion Injury?

Aretaieion University Hospital·observational·Posted Feb 5, 2020·Updated Feb 5, 2020

In Brief

An observational study evaluating selective hepatic vascular exclusion and semielective hepatic vascular exclusion for Ischemic Reperfusion Injury and 4 related conditions. Completed, enrolled 230 participants.

Detailed Summary

Severe ischemic changes of the liver remnant after hepatectomy could expedite tumor recurrence on the residual liver. Our study aimed at assessing the effect of warm ischemic/reperfusion (I/R) injuries on surgery-to-local recurrence interval and patient overall survival, during major hepatectomies under inflow and outflow vascular control.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsIschemic Reperfusion Injury, Liver Injury, Cancer Recurrence, Malignancy, Liver Cancer
Countries--
Collaborators--

Timeline

N/ACompletedFinished
2000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedFeb 5, 2020
Enrollment StartJan 1, 2000
Primary CompletionDec 31, 2012
TodayJul 2, 2026
Enrollment to primary: 13 yearsPosted 6.4 years ago

Interventions

selective hepatic vascular exclusionprocedure

major hepatectomy with vascular control of blood inflow and outflow of the whole liver

semielective hepatic vascular exclusionprocedure

major liver resection by selectively clamping the portal and hepatic vessels only of the lobe harboring the tumor