At a glance
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Wound Infiltration With Liposomal Bupivacaine With or Without Intrathecal Analgesia in Laparotomy for Gynecological Malignancy: A Randomized Controlled Trial
In Brief
A Phase 4 clinical trial evaluating Hydromorphone, Laparotomy, and 2 other interventions for Malignant Female Reproductive System Neoplasm. Completed, enrolled 105 participants across 1 site.
Detailed Summary
This phase IV trial studies how well liposomal bupivacaine with or without hydromorphone works in improving pain control during the first 24 hours after surgery in patients with gynecological malignancies undergoing laparotomy. Liposomal bupivacaine is routinely infiltrated into the skin surrounding the abdominal incision, and is effective in providing good relief of incisional pain. Hydromorphone is also a type of pain medication that may provide better management of deep abdominal pain. It is not yet known if giving liposomal bupivacaine with or without hydromorphone will work better in improving pain in patients with gynecological malignancies during the first 24 hours after surgery.
Study Details
Timeline
Interventions
Given IT
Undergo laparotomy
Drug
Ancillary studies