At a glance
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The Innate Central Nervous System Immune Response to an Experimental Immune Challenge in People With Fibromyalgia
In Brief
A Phase 3 clinical trial evaluating Endotoxin, Escherichia Coli and Magnetic Resonance Spectroscopy for Fibromyalgia. Completed, enrolled 36 participants across 1 site.
Detailed Summary
The major goal of this study is to determine if the innate immune response is dysregulated in people with fibromyalgia, compared to healthy controls. Magnetic resonance spectroscopy will be used to measure changes in the brain's metabolic profile following an experimental immune stimulus, to test whether individuals with fibromyalgia show a heightened immune response in the brain. The ultimate goal of this research is to better understand the role of brain inflammation in the pathophysiology of chronic pain and fatigue, which will guide the development of more effective therapies for these conditions.
Study Details
Timeline
Interventions
Endotoxin is a purified lipopolysaccharide prepared from E. coli O:113 and vialed under good manufacturing practice guidelines.
MRI is a non-invasive imaging technique and does not utilize ionizing radiation.