CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 97 enrolled
Drug / intervention
Polyethylene Glycol 3350drug
Likely dose
Polyethylene Glycol 3350 17gfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04263896
NCT04263896Phase 4Completed

Bowel Function After Minimally Invasive Hysterectomy: A Randomized Controlled Trial

University of Chicago·interventional·Posted Feb 11, 2020·Updated Aug 19, 2025

In Brief

A Phase 4 clinical trial evaluating Polyethylene Glycol 3350 for Constipation. Completed, enrolled 97 participants across 1 site.

Detailed Summary

Postoperative constipation affects up to a third of women undergoing minimally invasive (MIS) gynecologic surgery and is a major source of anxiety and discomfort. The average time to first bowel movement after gynecologic surgery is about 2 to 4 days and some factors responsible for this include anesthesia inhibitory effect on gastrointestinal motility, opioid pain medication use, chronic nonsteroidal anti-inflammatory drugs (NSAID) use and anatomic manipulation. There are no established regimens to manage postoperative constipation after minimally invasive gynecologic surgery. Two studies evaluating the implementation of postoperative bowel regimen with polyethylene glycol (PEG) and with Senna and Docusate found no significant impact on postoperative bowel function. There have been no studies looking at the effect of preoperative bowel regimens on postoperative bowel function. The purpose of this study is to evaluate postoperative bowel function after minimally invasive hysterectomy in women receiving a preoperative 10-day bowel regimen of PEG daily.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsConstipation
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
2020202120222023202420252026
First PostedFeb 11, 2020
Enrollment StartAug 28, 2019
Primary CompletionJun 30, 2024
Study CompletionJun 9, 2025
TodayJul 2, 2026
Enrollment to primary: 4.8 yearsPosted 6.4 years ago

Interventions

Polyethylene Glycol 3350drug

Participants will take 1 17g pack per day for 10 days preceding surgery.