CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 58 enrolled
Drug / intervention
DNA Analysis +3 moregenetic
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04273672
NCT04273672N/ACompleted
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Speech, Linguistic and Acoustic Markers in Parkinson's Disease

University of Massachusetts, Worcester·observational·Posted Feb 18, 2020·Updated Jun 10, 2025

In Brief

An observational study evaluating Cognitive Battery, Voice, Speech and Language Analysis, and 2 other interventions for Parkinson Disease and 2 related conditions. Completed, enrolled 58 participants across 1 site.

Detailed Summary

The Investigators aim to identify speech and language markers that provide information on cognitive function and predict cognitive decline in Parkinson's disease. The Investigators will administer speech tasks and cognitive assessments to participants with Parkinson's disease and healthy controls. The Investigators will also explore the associations between genetic factors and speech and cognitive status in Parkinson's disease.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsParkinson Disease, Cognitive Impairment, Mild, Speech
CountriesUnited States
CollaboratorsBoston University, VA Puget Sound Health Care System, National Institute on Deafness and Other Communication Disorders (NIDCD), Massachusetts Institute of Technology

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedFeb 18, 2020
Enrollment StartJan 13, 2020
Primary CompletionSep 1, 2023
Study CompletionFeb 28, 2025
TodayJul 2, 2026
Enrollment to primary: 3.6 yearsPosted 6.4 years ago

Interventions

Cognitive Batteryother

Participants will be asked to complete a series of cognitive testing (testing of concentration, memory, and other thinking abilities).

Voice, Speech and Language Analysisbehavioral

Participants will be asked to perform speaking and reading tasks, which will be recorded. Participants will be asked to complete a laptop-based test of language comprehension.

Questionnaires and Clinical Assessmentsbehavioral

Participants with Parkinson's disease will complete an examination of their symptoms and questionnaires assessing disease symptoms, mood and activities of daily living. Healthy controls participants will be asked to complete questionnaires on mood.

DNA Analysisgenetic

Participants will have their blood drawn for DNA analysis.