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N/ACompleted· 3 enrolled
Drug / intervention
periodontal surgery + 24 hr buccal attached gingiva (G) biopsy +1 moreprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

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NCT04276129N/ACompleted
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Early Healing of Oral Soft Tissues: a Clinical and Biomolecular Analysis. Part II - Effect of Local Chlorhexidine Administration in Gene Expression and Cellular Behaviour 24-hours After Injury

University of Roma La Sapienza·interventional·Posted Feb 19, 2020·Updated Mar 1, 2021

In Brief

A clinical study evaluating periodontal surgery + 24 hr buccal attached gingiva (G) biopsy and post-surgical CHX mouth-rinses indication for Wound Heal and 3 related conditions. Completed, enrolled 3 participants across 1 site.

Detailed Summary

The purpose of the present study is to evaluate the influence of the post-surgical chlorhexidine indication in the gene expression profile and cellular behavior in the early wound healing process -24 hours after injury- of the oral soft tissues. The main hypothesis is that the post-surgical use of chlorhexidine affects the gene expression and the celular behavior in the early wound healing process of the soft oral tissues.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsWound Heal, Wound Surgical, Oral Soft Tissue Conditions, Chlorhexidine Adverse Reaction
CountriesItaly
Collaborators--

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedFeb 19, 2020
Enrollment StartFeb 20, 2020
Primary CompletionOct 17, 2020
TodayJul 2, 2026
Enrollment to primary: 8 monthsPosted 6.4 years ago

Interventions

periodontal surgery + 24 hr buccal attached gingiva (G) biopsyprocedure

Periodontal surgery will be performed and 24 hr after the surgical procedure a 2mm punch biopsy will be harvested at the level of the buccal attache gingiva (G).

post-surgical CHX mouth-rinses indicationother

CHX mouth-rinses (0.12%) will be indicated 2 times/day after the surgical procedure