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At a glance

ClinicalIndex Comparison Record
N/ACompleted· 445 enrolled
Drug / intervention
clinical intervention for microbial analysis and MIR155 as biomarkerother
Likely dose
Not stated in record
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Search/NCT04277390
NCT04277390N/ACompleted
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Evidence Linking the Role of Viruses, Bacteria and Placental MIR155 in Chronic Periodontitis and Preeclampsia- A Genetic Microbiological Study

Meenakshi Ammal Dental College and Hospital·observational·Posted Feb 20, 2020·Updated Feb 25, 2020

In Brief

An observational study evaluating clinical intervention for microbial analysis and MIR155 as biomarker for Preeclampsia and Chronic Periodontitis. Completed, enrolled 445 participants across 1 site.

Detailed Summary

Preeclamptic women with and without chronic periodontitis were recruited for the study. Subgingival plaque samples and placental tissue samples(postpartum) were obtained from the participants for the microbial analysis(bacteria, viruses) and MIR155 levels and comparison was done among groups. this study was designed in order to evaluate the role of periodontal microorganisms in preeclampsia and to find compare the MIR155 levels among participants, so as to check its importance as a biomarker for inflammatory disease like preeclampsia.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsPreeclampsia, Chronic Periodontitis
CountriesIndia
Collaborators--

Timeline

N/ACompletedFinished
20162017201820192020202120222023202420252026
First PostedFeb 20, 2020
Enrollment StartAug 1, 2015
Primary CompletionAug 20, 2018
Study CompletionNov 10, 2019
TodayJul 2, 2026
Enrollment to primary: 3.1 yearsPosted 6.4 years ago

Interventions

clinical intervention for microbial analysis and MIR155 as biomarkerother

Subgingival plaque was collected with sterile curette and placental tissue sample(postpartum with surgical blade with the help of gynecologist. all the samples were subjected to RTPCR for analysis of microorganisms likeTannerella forsythia(Tf), Treponema denticola(Td), Porphyromonas gingivalis(Pg), Prevotella intermedia(Pi), Fusobacterium nucleatum(Fn). Herpes Simplex Virus(HSV), Ebstein Barr Virus(EBV), Human Cytomegalovirus(HCMV). and MIR155 levels were also estimated