CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 11 enrolled
Drug / intervention
Alcohol +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04300751
NCT04300751Phase 1Completed
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Interactions of Alcohol and Opioids: Pharmacodynamic Effects

Sharon Walsh·interventional·Posted Mar 9, 2020·Updated Nov 20, 2025

In Brief

A Phase 1 clinical trial evaluating Alcohol and Opioid Agonist for Opioid Use and Alcohol Drinking. Completed, enrolled 11 participants across 1 site.

Detailed Summary

This study will examine the effects of doses of alcohol/placebo and doses of opioid/placebo, alone and in combination. The primary outcomes are related to pharmacodynamic measures (subjective ratings of drug liking and other abuse-related effects; physiological outcomes) to determine the interaction effects of these compounds.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsOpioid Use, Alcohol Drinking
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)

Timeline

Phase 1CompletedFinished
202120222023202420252026
First PostedMar 9, 2020
Enrollment StartMar 24, 2021
Primary CompletionNov 9, 2024
TodayJul 2, 2026
Enrollment to primary: 3.6 yearsPosted 6.3 years ago

Interventions

Alcoholdrug

Active alcohol or placebo, administered orally

Opioid Agonistdrug

Active opioid agonist or placebo, administered orally