CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 13 enrolled
Drug / intervention
TCD601 +4 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04311632
NCT04311632Phase 2Completed

A 12-Month, Randomized, Controlled, Open-Label, Dose Escalation Study Evaluating Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of an Anti-CD2 Monoclonal Antibody, TCD601(Siplizumab) Compared to Anti-thymocyte Globulin (rATG), as Induction Therapy in de Novo Renal Transplant Recipients

ITB-Med LLC·interventional·Posted Mar 17, 2020·Updated Feb 27, 2025

In Brief

A Phase 2 clinical trial evaluating TCD601, Tacrolimus (TAC), and 3 other interventions for Kidney Transplantation. Completed, enrolled 13 participants across 4 sites.

Detailed Summary

The purpose of this study is to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of escalating doses of TCD601 when compared to rATG in de novo renal transplant patients.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
202120222023202420252026
First PostedMar 17, 2020
Enrollment StartMay 26, 2021
Primary CompletionOct 3, 2023
TodayJul 2, 2026
Enrollment to primary: 2.4 yearsPosted 6.3 years ago

Interventions

TCD601biological

Investigational Product

Tacrolimus (TAC)drug

Standard of Care Concomitant Immunosuppression

Corticosteroids (CS)drug

Standard of Care Concomitant Immunosuppression

Mycophenolate Mofetil (MMF)drug

Standard of Care Concomitant Immunosuppression

ATGdrug

Standard of Care induction therapy in solid organ transplantation