At a glance
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Do Peri-operative High Doses of Intravenous Glucocorticoids Improve Short-term Functional Outcome After Direct Anterior Total Hip Arthroplasty? A Randomized, Single Surgeon, Placebo Controlled, Double Blind Study
In Brief
A clinical study evaluating High dose of peri-operative intravenous dexamethasone and Low dose of peri-operative intravenous dexamethasone for Coxarthrosis and Avascular Necrosis of Hip. Completed, enrolled 71 participants across 1 site.
Detailed Summary
This randomized, single surgeon, placebo controlled, double blind study will be conducted in order to investigate whether or not peri-operative high doses of intravenous glucocorticoids improve short-term functional outcome after direct anterior total hip arthroplasty. So far, it has been proven that high dose glucocorticoids reduce immediate post-operative pain and nausea, but no data exists on functional outcome during the first 6 weeks. Our hypothesis is that patients in the intervention group will follow a so-called "get ahead, stay ahead" principle and that glucocorticoids can be considered an important tool (adjuvant treatment) in the enhanced recovery pathway after THA with significant socio-economic implications.
Study Details
Timeline
Interventions
25mg aacidexam is administered during induction followed by 10mg on the ward after 12 hours
10mg aacidexam is administered during induction followed by placebo on the ward after 12 hours