CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 3,433 enrolled
Drug / intervention
Beclomethasone Dipropionate +2 moredrug
Likely dose
Beclomethasone Dipropionate 12.5μgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04320342
NCT04320342Phase 3Completed

A Phase III, 52-week, Multinational, Multicenter, Randomized, Double-blind, 2-arm Parallel Group Study Comparing Efficacy, Safety and Tolerability of the Fixed Dose Triple Combination of Beclomethasone Dipropionate Plus Formoterol Fumarate Plus Glycopyrronium Bromide (CHF 5993) With the Fixed Dose Dual Combination of Beclomethasone Dipropionate Plus Formoterol Fumarate (CHF 1535), Both Administered Via pMDI in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Chiesi Farmaceutici S.p.A.·interventional·Posted Mar 25, 2020·Updated Jan 30, 2026

In Brief

A Phase 3 clinical trial evaluating Beclomethasone Dipropionate, Glycopyrronium Bromide, and 1 other intervention for COPD and COPD Exacerbation. Completed, enrolled 3,433 participants across 436 sites in 10 countries.

Detailed Summary

The purpose of this study is to compare CHF 5993 with CHF 1535 in improving lung function, reducing moderate and severe COPD exacerbations, and other clinical efficacy and safety outcomes in the target subject population.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesArgentina, Bulgaria, Canada, Czechia, Hungary, Mexico, Poland, Puerto Rico, Romania, United States
Collaborators--

Timeline

Phase 3CompletedFinished
202120222023202420252026
First PostedMar 25, 2020
Enrollment StartApr 28, 2022
Primary CompletionJan 12, 2026
TodayJul 2, 2026
Enrollment to primary: 3.7 yearsPosted 6.3 years ago

Interventions

Beclomethasone Dipropionatedrug

Available in pressurized inhalation solution BDP/FF/GB 100/6/12.5μg and BDP/FF 100/6μg

Glycopyrronium Bromidedrug

Available in pressurized inhalation solution BDP/FF/GB 100/6/12.5μg

Formoterol Fumaratedrug

Available in pressurized inhalation solution BDP/FF/GB 100/6/12.5μg and BDP/FF 100/6μg