At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Impact and Interplay of Corticosteroid Regimen and Exercise Training on DMD Muscle Function
In Brief
A Phase 2 clinical trial evaluating Prednisone, Exercise Training on standard steroid regimen, and 1 other intervention for Duchenne Muscular Dystrophy (DMD). Completed, enrolled 21 participants across 1 site.
Detailed Summary
The study team will determine the potential of low dose twice weekly prednisone and whether exercise training can synergize to delay disease progression and improve muscle strength/physical function in boys with Duchenne muscular dystrophy (DMD). Current standard of care (daily prednisone) is associated with adverse side effects. Evidence from DMD mouse models suggest that weekly dosing provides same efficacy without side effects. Appropriate exercise may also benefit but this area has not been adequately explored.
Study Details
Timeline
Interventions
A 12-month treatment period with twice weekly, low-dose prednisone (dose of 0.75 mg/kg per day).
For boys on current standard of care (daily glucocorticoid use), 6-months in-home, remotely supervised exercise training program involving a combination of aerobic and isometric leg strength exercises.
Twice weekly prednisone for 6 months followed by twice weekly prednisone plus exercise for 6 months.