CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 48 enrolled / 48 target
Drug / intervention
MeDALL questionnaire for allergic diseases +5 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04322838
NCT04322838N/ACompletedOn Track (0.7/mo)
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Tromsø Birch Rust Allergy Study. Allergy to Birch Rust Fungi, a Possible Explanation to Seasonal Airway Allergy During Autumn? A Pilot Study With 30 Patients With Suspected Allergy to Birch Rust and 15 Non-allergic Controls.

University Hospital of North Norway·observational·Posted Mar 26, 2020·Updated Jun 17, 2026

In Brief

An observational study evaluating MeDALL questionnaire for allergic diseases, Registration of allergic symptoms, and 4 other interventions for Hypersensitivity, Immediate and Allergy. Completed, enrolled 48 participants across 1 site.

Detailed Summary

In this project we study if spores from birch rust fungi (Melampsoridium Betulinum = MB) may be the eliciting allergen in patients with seasonal airway allergy during autumn in North Norway. Patients with suspected allergy to MB are compared with non-allergic controls using data about allergic disease and daily allergic symptoms during autumn. Daily spread of MB spores are compared with daily variations in allergic symptoms. Sensitization to MB and MB allergy are tested with skin prick test, specific immunoglobulin E (IgE) in serum, nasal provocation test and basophil activation test (BAT).

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsHypersensitivity, Immediate, Allergy
CountriesNorway
CollaboratorsLuxembourg Institute of Health, Oslo University Hospital

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedMar 26, 2020
Enrollment StartAug 1, 2020
Primary CompletionJun 16, 2026
TodayJul 2, 2026
Enrollment to primary: 5.9 yearsPosted 6.3 years ago

Arms & Interventions

Patientsother

30 patients with self-reported seasonal allergic airway symptoms in the period from 1st of August to 15.th of october

Diagnostic Test: MeDALL questionnaire for allergic diseasesDiagnostic Test: Registration of allergic symptomsDiagnostic Test: Skin Prick TestDiagnostic Test: Specific IgE in serumDiagnostic Test: Nasal provocation testDiagnostic Test: Basophil Activation Test
Controlsother

15 non-allergic individuals

Diagnostic Test: MeDALL questionnaire for allergic diseasesDiagnostic Test: Registration of allergic symptomsDiagnostic Test: Skin Prick TestDiagnostic Test: Specific IgE in serumDiagnostic Test: Nasal provocation testDiagnostic Test: Basophil Activation Test

Interventions

MeDALL questionnaire for allergic diseasesother

Questionnaire about allergic symptoms and disease

Registration of allergic symptomsother

Daily registration of allergic symptoms from eyes, nose and lungs on scale from 0-10 and daily registration of use of anti allergic medication from 1st of August to 15th of October.

Skin Prick Testother

Diagnostic skin test for sensitization to allergens

Specific IgE in serumother

Diagnostic test for sensitization to allergens in serum

Nasal provocation testother

Diagnostic test for allergic rhinitis. Patients and controls are exposed to an allergen with a nasal spray. Allergic reactions are measured with Linder score and Pean Nasal Inspiratory Flow (PNIF)

Basophil Activation Testother

Basophil leukocytes are extracted from full blood and exposed to 6 different doses of allergen and activation of basophils are measured.