CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 41 enrolled
Drug / intervention
A single low dose ketamine infusion as compared to the IV infusion of active placebo - ketorolac on chronic pain and PTSD symptoms.drug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04322968
NCT04322968Phase 3Completed
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Low Dose Ketamine Infusion for Comorbid Posttraumatic Stress Disorder and Chronic Pain Patients

VA Ann Arbor Healthcare System·interventional·Posted Mar 26, 2020·Updated Dec 22, 2020

In Brief

A Phase 3 clinical trial evaluating A single low dose ketamine infusion as compared to the IV infusion of active placebo - ketorolac on chronic pain and PTSD symptoms. for PTSD and Chronic Pain. Completed, enrolled 41 participants across 1 site.

Detailed Summary

The purpose of the study is to investigate the effectiveness of low dose IV ketamine infusion in the treatment of patients with PTSD and comorbid chronic pain. Hypothesis: A single ketamine infusion should be associated with significantly greater reduction in core PTSD symptom levels after the treatment and such an effect is not only due to its analgesic properties but also through unknown mechanism of action that maybe related to NMDA/AMPA receptor modulation.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPTSD, Chronic Pain
CountriesUnited States
CollaboratorsUniversity of Michigan

Timeline

Phase 3CompletedFinished
201820192020202120222023202420252026
First PostedMar 26, 2020
Enrollment StartJan 9, 2018
Primary CompletionJun 4, 2019
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 6.3 years ago

Interventions

A single low dose ketamine infusion as compared to the IV infusion of active placebo - ketorolac on chronic pain and PTSD symptoms.drug

Subjects were randomized into 4 treatment groups: chronic pain subjects treated with ketorolac, chronic pain subjects treated with ketamine, chronic pain+PTSD subjects treated with ketorolac, and chronic pain+PTSD subjects treated with ketamine.