CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 159 enrolled
Drug / intervention
Verinurad +3 moredrug
Likely dose
Verinurad 3 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04327024
NCT04327024Phase 2Completed
CompareCT.gov

A Phase 2, Multicentre, Double-Blind, Placebo and Active Control Efficacy and Safety Study to Evaluate Verinurad Combined With Allopurinol in Heart Failure With Preserved Ejection Fraction

AstraZeneca·interventional·Posted Mar 30, 2020·Updated Jun 29, 2023

In Brief

A Phase 2 clinical trial evaluating Verinurad, Allopurinol, and 2 other interventions for Heart Failure With Preserved Ejection Fraction (HFpEF). Completed, enrolled 159 participants across 58 sites in 12 countries.

Detailed Summary

International, Multicenter, Double-Blind, Placebo and Active Control Efficacy and Safety Study to Evaluate Verinurad combined with Allopurinol in Heart Failure with Preserved Ejection Fraction

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHeart Failure With Preserved Ejection Fraction (HFpEF)
CountriesArgentina, Australia, Austria, Bulgaria, Canada, Germany, Mexico, Poland, Russia, Slovakia, South Korea, United States
Collaborators--

Timeline

Phase 2CompletedFinished
202120222023202420252026
First PostedMar 30, 2020
Enrollment StartMay 19, 2020
Primary CompletionApr 29, 2022
TodayJul 2, 2026
Enrollment to primary: 1.9 yearsPosted 6.3 years ago

Interventions

Verinuraddrug

The treatment will be titrated in 3 steps for target low dose (3 mg), intermediate dose (7.5 mg) and high dose (12mg) of verinurad. Drug: Allopurinol The treatment will be titrated in 3 steps. Low dose (100mg), intermediate (200mg) and high dose (300mg) of allopurinol.

Allopurinoldrug

Study treatments will be titrated in 3 steps: Low dose (100mg), intermediate (200mg) and high dose (300mg) of allopurinol

Placebo for verinuraddrug

Matching Capsule

Placebo for allopurinoldrug

Matching tablet