At a glance
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Effectiveness of Nebulized Dexmedetomidine for Treatment of Post-Dural Puncture Headache in Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia: Randomized Controlled Study
In Brief
A clinical study evaluating Dexmedetomidine Nebulization and 0.9% Saline Nebulization for Post-Dural Puncture Headache. Completed, enrolled 43 participants across 1 site.
Detailed Summary
Postdural puncture headache (PDPH) is a common complication, following neuraxial techniques. The obstetric population is particularly prone to PDPH. Therefore, treatment of PDPH is a key issue in obstetric anesthesia. Dexmedetomidine is a highly selective, centrally acting α2-adrenergic agonist with analgesic and anxiolytic effects. Moreover, it decreases cerebral blood flow (CBF) in humans and animals secondary to cerebrovascular vasoconstriction. It has been used via the intranasal and inhalational routes for many purposes including premedication, sedation and postoperative analgesia. Because of its desirable properties, we hypothesized that dexmedetomidine nebulization could be effective in the treatment of patients suffering from PDPH after caesarean section.
Study Details
Timeline
Interventions
ultrasonic nebulization of 1 µg/kg dexmedetomidine for PDPH treatment
nebulization of 4mL 0.9% saline