CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 101 enrolled
Drug / intervention
TERN-101 +1 moredrug
Likely dose
Not stated in record
Key inclusion· 5
  • Age 18–75 years
  • Overweight or obese: BMI ≥25 kg/m²
  • Presumed NASH confirmed by clinical characteristics or prior biopsy
  • Elevated ALT: ≥43 IU/L (men), ≥28 IU/L (women)
Key exclusion· 7
  • Other chronic liver diseases besides NAFLD
  • Cirrhosis, hepatic decompensation, or severe liver impairment
  • History of liver transplant or current listing
  • Weight loss >5% within 3 months prior to screening

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04328077
NCT04328077Phase 2Completed

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2a Clinical Trial to Evaluate the Safety, Tolerability, Efficacy, and Pharmacokinetics of Orally Administered TERN-101 Tablets in Adult Patients With Presumed Non-Cirrhotic Non-Alcoholic Steatohepatitis (NASH)

Terns, Inc.·interventional·Posted Mar 31, 2020·Updated Aug 9, 2022

In Brief

A Phase 2 clinical trial evaluating TERN-101 and Placebo for NASH - Nonalcoholic Steatohepatitis. Completed, enrolled 101 participants across 31 sites.

Detailed Summary

This is a Phase 2, randomized, double-blind, placebo-controlled study designed to evaluate the safety, tolerability, efficacy, and pharmacokinetics (PK) of TERN-101 in non-cirrhotic NASH patients.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
202120222023202420252026
First PostedMar 31, 2020
Enrollment StartJun 18, 2020
Primary CompletionMay 19, 2021
TodayJul 2, 2026
Enrollment to primary: 11 monthsPosted 6.3 years ago

Interventions

TERN-101drug

Investigational drug

Placeboother

Matching placebo