CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 356 enrolled
Drug / intervention
75 mg linzagolix tablet +5 moredrug
Likely dose
75 mg linzagolix tabletfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04335591
NCT04335591Phase 3Completed

A Double-blind Randomized Extension Study to Assess the Long-term Efficacy and Safety of Linzagolix in Subjects With Endometriosis-associated Pain

Kissei Pharmaceutical Co., Ltd.·interventional·Posted Apr 6, 2020·Updated Apr 2, 2025

In Brief

A Phase 3 clinical trial evaluating 75 mg linzagolix tablet, 200 mg linzagolix tablet, and 4 other interventions for Endometriosis. Completed, enrolled 356 participants across 47 sites in 9 countries.

Detailed Summary

The primary objective of this extension study is to assess the maintenance of efficacy of linzagolix administered orally once daily for up to an additional 6 months (for up to 12 months of treatment in total) in women who have already completed 6 months of linzagolix treatment at a dose of 75 mg alone or of 200 mg in combination with ABT (E2 1 mg / NETA 0.5 mg), in the management of moderate to severe endometriosis-associated pain (EAP) in women with surgically confirmed endometriosis.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsEndometriosis
CountriesAustria, Bulgaria, Czechia, France, Poland, Romania, Spain, Ukraine, United States
Collaborators--

Timeline

Phase 3CompletedFinished
2020202120222023202420252026
First PostedApr 6, 2020
Enrollment StartMar 5, 2020
Primary CompletionSep 15, 2022
Study CompletionDec 15, 2022
TodayJul 2, 2026
Enrollment to primary: 2.5 yearsPosted 6.2 years ago

Interventions

75 mg linzagolix tabletdrug

For oral administration once daily

200 mg linzagolix tabletdrug

For oral administration once daily

Placebo tablet to match 75 mg linzagolix tabletdrug

For oral administration once daily

Placebo tablet to match 200 mg linzagolix tabletdrug

For oral administration once daily

Add-back capsule (E2 1 mg / NETA 0.5 mg)drug

For oral administration once daily

Placebo capsule to match Add-back capsuledrug

For oral administration once daily