CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 38 enrolled
Drug / intervention
Gait training performed on a treadmill +1 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04340063
NCT04340063N/ACompleted

Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury (AGILE SCI) Trial

VA Office of Research and Development·interventional·Posted Apr 9, 2020·Updated May 29, 2025

In Brief

A clinical study evaluating Gait training performed on a treadmill and Gait training performed in a Movement Amplification Environment for Incomplete Spinal Cord Injury. Completed, enrolled 38 participants across 1 site.

Detailed Summary

Spinal cord injury (SCI) affects \~42,000 Veterans. The VA provides the single largest network of SCI care in the nation. The lifetime financial burden of SCI can exceed $3 million. A major cost of SCI is impaired mobility. Limited mobility contributes to decreased ability to work, increased care requirements, secondary injury, depression, bone mineral density loss, diabetes, and decreased cardiovascular health. Among ambulatory individuals with iSCI, residual balance deficits are common and are strongly correlated with both functional walking ability and participation in walking activities. The development of effective rehabilitation tools to improve dynamic balance would substantially improve quality of life for Veterans living with iSCI. Improving mobility through interventions that enhance dynamic balance would positively impact health, independence, and the ability to integrate into social, intellectual, and occupational environments.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedApr 9, 2020
Enrollment StartOct 15, 2020
Primary CompletionMar 31, 2024
TodayJul 2, 2026
Enrollment to primary: 3.5 yearsPosted 6.2 years ago

Interventions

Gait training performed on a treadmilldevice

Participants randomized to the Control group will complete high intensity gait training on a treadmill.

Gait training performed in a Movement Amplification Environmentdevice

The Experimental group will perform all gait training within the movement amplification environment. To create the movement amplification environment, the investigators have constructed a cable-driven robot, the Agility Trainer. The Agility Trainer applies small forces to the pelvis that increase the difficulty to maintain forward walking