CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 16 enrolled
Drug / intervention
VX-147drug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04340362
NCT04340362Phase 2Completed

A Phase 2a, Open-label, Single-arm, 2-Part Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis

Vertex Pharmaceuticals Incorporated·interventional·Posted Apr 9, 2020·Updated Sep 24, 2025

In Brief

A Phase 2 clinical trial evaluating VX-147 for Glomerulosclerosis, Focal Segmental. Completed, enrolled 16 participants across 44 sites in 4 countries.

Detailed Summary

This study will evaluate the efficacy, safety and pharmacokinetics (PK) of VX-147 in participants with apolipoprotein L1 (APOL1)-mediated focal segmental glomerulosclerosis (FSGS).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesFrance, Puerto Rico, United Kingdom, United States
Collaborators--

Timeline

Phase 2CompletedFinished
202120222023202420252026
First PostedApr 9, 2020
Enrollment StartJun 8, 2020
Primary CompletionNov 11, 2021
Study CompletionDec 9, 2021
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 6.2 years ago

Interventions

VX-147drug

Tablets for oral administration.