CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 287 enrolled
Drug / intervention
True Cognitive Training Program +3 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04344028
NCT04344028N/ACompleted

Examining the Potential for Placebo Effects in Cognitive Training

University of Wisconsin, Madison·interventional·Posted Apr 14, 2020·Updated May 6, 2025

In Brief

A clinical study evaluating True Cognitive Training Program, Control Cognitive Training Program, and 2 other interventions for Cognitive Change. Completed, enrolled 287 participants across 3 sites.

Detailed Summary

The present study addresses whether placebo effects can possibly account for previous findings in the field, as well as ascertains whether placebo-based mechanisms can be deliberately harnessed for impact. The design is a 2 (positive expectations/negative expectations) x 2 (true cognitive training intervention x control cognitive training intervention) Randomized Controlled Trial (RCT). Participants will be recruited from site-affiliated participant pools or email lists. Participants will first undergo a pre-test battery where various cognitive abilities are assessed via computerized programs. They will also fill out various surveys about personality traits/internal dispositions that may predict the extent to which they are susceptible to placebo effects. After pre-testing, participants will be randomized to an expectations group (positive/negative) and a training protocol (active/control). Participants are then given their group appropriate expectation script. In the positive expectations group, participants receive training described as having previous research supporting its use as a method to enhance cognitive abilities. In the negative expectations group, participants receive training described as having previous research suggesting that it is unlikely to change cognitive abilities or may even decrease cognitive abilities. The participants will then be given instructions regarding how to do their training task. Participants will be asked to complete 10 sessions of training within 15 days. The active training will be a standard working memory (N-back) training task. The control training will be a trivia/quiz training task. After they have completed 10 sessions, participants will complete a "mid-test" session to undergo a battery of perceptual/cognitive tasks. Participants will be told that the perceptual/cognitive tests are identical to those that they took at pre-test. However, in reality, for participants in the "positive expectations" groups, these will be altered to actually be easier than they were at pre-test. For participants in the "negative expectations" groups the tasks will be made more difficult. Participants will then be asked to complete another set of 10 training sessions on their devices within 15 days before completing the post-test. The post-test will be identical to the pre-test. All participants will then be extensively debriefed (e.g., all deceptions will be made clear). On a separate day, participants will then complete a second post-test that is identical to the pre-test and first-post test.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedApr 14, 2020
Enrollment StartMay 11, 2020
Primary CompletionAug 9, 2022
TodayJul 2, 2026
Enrollment to primary: 2.2 yearsPosted 6.2 years ago

Interventions

True Cognitive Training Programbehavioral

The training program is a personal device-based adaptive version of a visual N-back task.

Control Cognitive Training Programbehavioral

The training program is a personal device-based adaptive version of a knowledge task (control).

Positive Expectation Inductionbehavioral

The message given to the participants emphasizes that the given training results in a positive change in cognitive abilities.

Negative Expectation Inductionbehavioral

The message given to the participants emphasizes that the given training results in a negative change in cognitive abilities.