At a glance
ClinicalIndex Comparison Record- ✓Medically uncontrolled glaucoma despite pharmacologic therapy
- ✓Healthy and freely mobile conjunctiva in the superior bulbar region (required for surgical access)
- ✕Prior incisional glaucoma surgery
- ✕No light perception vision
- ✕Pregnant or nursing women
- ✕Iris neovascularization or proliferative retinopathy
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Subconjunctival Versus Direct Scleral Application of Mitomycin-C in Trabeculectomy
In Brief
A Phase 4 clinical trial evaluating Mitomycin-C injection and Mitomycin-C sponge for Open Angle Glaucoma. Completed, enrolled 100 participants.
Detailed Summary
Trabeculectomy is routinely used as a surgical treatment for open angle glaucoma. Success of trabeculectomy is greatly augmented by the use of antimetabolites to inhibit wound healing, specifically Mitomycin C (MMC). MMC can be applied to the eye at various sites, concentrations and times. This study aims to compare the two application routes that are commonly employed: subconjunctival pre-operative injection and intraoperative direct scleral application in terms of IOP lowering effect, bleb appearance and complications.
Study Details
Timeline
Interventions
MMC delivered by preoperative subconjunctival injection
MMC delivered by intraoperative direct scleral application with impregnated cellulose sponges