At a glance

ClinicalIndex Comparison Record

Phase 2Completed· 24 enrolled

Drug / intervention

Umbilical Cord Mesenchymal Stem Cells + Heparin along with best supportive care. +1 morebiological

Likely dose

Not stated in record

Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04355728

NCT04355728Phase 2Completed

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Umbilical Cord-derived Mesenchymal Stem Cells for COVID-19 Patients With Acute Respiratory Distress Syndrome (ARDS)

Camillo Ricordi·interventional·Posted Apr 21, 2020·Updated Dec 6, 2021

In Brief

A Phase 2 clinical trial evaluating Umbilical Cord Mesenchymal Stem Cells + Heparin along with best supportive care. and Vehicle + Heparin along with best supportive care for Corona Virus Infection and 4 related conditions. Completed, enrolled 24 participants across 1 site.

Detailed Summary

The purpose of this research study is to learn about the safety and efficacy of human umbilical cord derived Mesenchymal Stem Cells (UC-MSC) for treatment of COVID-19 Patients with Severe Complications of Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS).

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsCorona Virus Infection, ARDS, ARDS, Human, Acute Respiratory Distress Syndrome, COVID-19

CountriesUnited States

Collaborators--

Timeline

Phase 2CompletedFinished

202120222023202420252026

First PostedApr 2020

Enrollment StartApr 2020

Primary CompletionOct 2020

TodayJul 2026

First PostedApr 21, 2020

Enrollment StartApr 25, 2020

Primary CompletionOct 31, 2020

TodayJul 2, 2026

Enrollment to primary: 6 monthsPosted 6.2 years ago

Interventions

Umbilical Cord Mesenchymal Stem Cells + Heparin along with best supportive care.biological

UC-MSC will be administered at 100x10\^6 cells/infusion administered intravenously in addition to the standard of care treatment.

Vehicle + Heparin along with best supportive careother

Best supportive care treatment per the treating hospital protocol.