At a glance
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Beige Fat, Energy, and the Natriuretic Peptide System (ENDA-025-17S)
In Brief
An observational study for Obesity. Completed, enrolled 137 participants across 2 sites.
Detailed Summary
Obese individuals experience an increased risk of cardiovascular and metabolic diseases. Evidence from genetic studies indicate that the natriuretic peptide (NP) system may protect against these diseases. NP levels differ by obesity status and race has not been established in humans. Thus, the investigators propose a study in which will quantify adipose tissue gene expression and energy expenditure in states of NP deficiency in humans. The overarching postulate is that obese and black individuals have NP deficiencies that contribute to less beige adipose tissue and lower energy expenditure.