CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 208 enrolled
Drug / intervention
active tDCS paired with active MBM +3 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04375072
NCT04375072N/ACompleted
CompareCT.gov

Combination Therapy of Home-based Transcranial Direct Current Stimulation and Mindfulness-based Meditation for Self-management of Clinical Pain and Symptoms in Older Adults With Knee Osteoarthritis

University of Arizona·interventional·Posted May 5, 2020·Updated Nov 12, 2025

In Brief

A clinical study evaluating active tDCS paired with active MBM, sham tDCS paired with active MBM, and 2 other interventions for Osteo Arthritis Knee. Completed, enrolled 208 participants across 1 site.

Detailed Summary

This clinical trial aims to evaluate whether a 2 week regimen of transcranial direct current stimulation (tDCS) paired with mindfulness-based meditation (MBM) can improve pain modulation, reduce clinical pain, and alleviate osteoarthritis (OA)-related symptoms in patients with knee OA.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsOsteo Arthritis Knee
CountriesUnited States
CollaboratorsNational Institute of Nursing Research (NINR)

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedMay 5, 2020
Enrollment StartAug 13, 2020
Primary CompletionJan 30, 2025
TodayJul 2, 2026
Enrollment to primary: 4.5 yearsPosted 6.2 years ago

Interventions

active tDCS paired with active MBMdevice

Active tDCS with a constant current intensity of 2 milli ampere (mA) will be applied for 20 minutes per session daily for 2 weeks via the Soterix 1x1 tDCS mini-CT Stimulator device with headgear and saline-soaked surface sponge electrodes. The meditation intervention will be applied simultaneously with tDCS for 20 minutes per session daily for 2 weeks by a recorded meditation.

sham tDCS paired with active MBMdevice

For sham stimulation, the electrodes will be placed in the same positions as for active stimulation, but the stimulator will only deliver 2 mA current for 30 seconds during each 20-minute session, conducted daily for 2 weeks. The meditation intervention will be applied simultaneously with tDCS for 20 minutes per session daily for 2 weeks by a recorded meditation.

active tDCS paired with sham MBMdevice

Active tDCS with a constant current intensity of 2 milli ampere (mA) will be applied for 20 minutes per session daily for 2 weeks via the Soterix 1x1 tDCS mini-CT Stimulator device with headgear and saline-soaked surface sponge electrodes. The sham MBM intervention will be delivered via a CD player that will look identical in both active and sham MBM.

sham tDCS paired with sham MBMdevice

For sham stimulation, the electrodes will be placed in the same positions as for active stimulation, but the stimulator will only deliver 2 mA current for 30 seconds during each 20-minute session, conducted daily for 2 weeks. The sham MBM intervention will be delivered via a CD player that will look identical in both active and sham MBM.