At a glance
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Evaluation of Neurocognitive Changes in Parkinson's Disease Patients Following Acute Low Frequency Deep Brain Stimulation
In Brief
A clinical study evaluating STN DBS 10Hz, STN DBS 130Hz, and 1 other intervention for Parkinson Disease. Completed, enrolled 12 participants across 1 site.
Detailed Summary
Rationale: Parkinson's disease patients with deep brain stimulation electrodes represent a unique opportunity to study the influence of basal ganglia on neurocognitive function. Intervention: Patients' deep brain stimulators will be turned off or on and the frequency will be changed to either theta or gamma. Objectives: To identify differences in higher cognitive functions with stimulation "on" and "off" and theta versus gamma frequency stimulation. Study population: 12 patients who had previously undergone bilateral STN deep brain stimulation implantation. Study methodology: Patients will undergo four sessions of neuropsychological testing (RNGT, verbal fluency, D-KEFS CWIT) at baseline, no stimulation, theta stimulation and gamma stimulation, in random order over one day. Study outcomes: Test results of RNGT, verbal fluency, D-KEFS CWIT. Follow-up: none Statistics: Test results will be analyzed using within-subjects statistical tests.
Study Details
Timeline
Interventions
Stimulation of existing DBS device at 100Hz, with other parameters at baseline
Stimulation of existing DBS device at 130Hz, with other parameters at baseline
Existing DBS device turned off