CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 40 enrolled
Drug / intervention
APR-246 (eprenetapopt) + Pembrolizumabdrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04383938
NCT04383938Phase 2Completed

Study of APR-246 in Combination With Pembrolizumab in Subjects With Solid Tumor Malignancies

Aprea Therapeutics·interventional·Posted May 12, 2020·Updated May 13, 2025

In Brief

A Phase 2 clinical trial evaluating APR-246 (eprenetapopt) + Pembrolizumab for Bladder Cancer and 5 related conditions. Completed, enrolled 40 participants across 8 sites.

Detailed Summary

A phase 1/2, open-label, study to determine the safety and preliminary efficacy of APR-246 in combination with pembrolizumab in subjects with solid tumor malignancies. The study will include a safety lead-in portion followed by a phase 2 expansion portion in specific disease groups.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
202120222023202420252026
First PostedMay 12, 2020
Enrollment StartJun 25, 2020
Primary CompletionApr 30, 2022
TodayJul 2, 2026
Enrollment to primary: 1.8 yearsPosted 6.1 years ago

Interventions

APR-246 (eprenetapopt) + Pembrolizumabdrug

APR-246 D1-4 + Pembrolizumab D3