At a glance
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Randomized, Double Blind, Placebo Controlled Study to Evaluate the Effect of Dupilumab on Airway Inflammation Through Assessments of Lung Function, Mucus Plugging and Other Lung Imaging Parameters in Patients With Asthma
In Brief
A Phase 4 clinical trial evaluating Dupilumab and Placebo for Asthma. Completed, enrolled 109 participants across 65 sites in 13 countries.
Detailed Summary
Primary Objective: • To assess the effect of dupilumab on lung inflammation and related changes in airway volumes detectable by functional respiratory imaging Secondary Objective: * To evaluate the effect of dupilumab at Week 24 on bronchodynamics, hyperinflation, airway resistance, airway wall thickness, ventilation defects and mucus plugging derived from high-resolution computed tomography (HRCT) scans, patient-reported outcomes, FeNO and spirometry. * To evaluate safety of dupilumab
Study Details
Timeline
Interventions
solution for injection subcutaneous
Solution for injection subcutaneous