At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age
In Brief
A Phase 2 clinical trial evaluating Placebos and 20mg sodium nitrite tid for Aging and 2 related conditions. Completed, enrolled 64 participants across 1 site.
Detailed Summary
This 2-site randomized double blinded controlled trial is to confirm and more definitively clarify the impact of a 12-week course of nitrite versus placebo on mitochondrial bioenergetics in older sedentary adults. This investigator will take an integrative physiology approach to determine the effect of nitrite therapy on a comprehensive assessment of mitochondrial energetics, skeletal muscle vascular function, and whole body physical function (cardiorespiratory function, exercise endurance, strength, balance, and physical activity) and fatigability.
Study Details
Timeline
Interventions
Oral placebo capsule at a dose of 20 mg administered three times per day, during the day.
Oral, inorganic sodium nitrite capsule at a dose of 20 mg administered three times per day, during the day.