CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 84 enrolled
Drug / intervention
VIR-2218 +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04412863
NCT04412863Phase 2Completed

A Phase 1/2 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of VIR-2218 Alone or in Combination With Pegylated Interferon Alpha-2a

Vir Biotechnology, Inc.·interventional·Posted Jun 2, 2020·Updated Apr 16, 2026

In Brief

A Phase 2 clinical trial evaluating VIR-2218 and pegylated interferon-alfa 2a for Chronic Hepatitis B. Completed, enrolled 84 participants across 22 sites in 6 countries.

Detailed Summary

This is a phase 2 study in which subjects with chronic hepatitis B virus (HBV) infection will receive VIR-2218 alone or in combination with pegylated interferon alfa-2a and will be assessed for safety, tolerability, pharmacokinetics, and antiviral activity.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustralia, Hong Kong, Malaysia, New Zealand, South Korea, Thailand

Timeline

Phase 2CompletedFinished
202120222023202420252026
First PostedJun 2, 2020
Enrollment StartJul 3, 2020
Primary CompletionMar 25, 2024
TodayJul 2, 2026
Enrollment to primary: 3.7 yearsPosted 6.1 years ago

Interventions

VIR-2218drug

VIR-2218 given by subcutaneous injection

pegylated interferon-alfa 2adrug

pegylated interferon-alfa 2a given by subcutaneous injection