CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 36 enrolled
Drug / intervention
Paracetamol injection and Ibuprofen injection +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04414995
NCT04414995Phase 3Completed
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Effect of Paracetamol and Ibuprofen When Intravenously Given Combination or Alone in Reducing Morphine Requirements After Total Knee Arthroplasty

Indonesia University·interventional·Posted Jun 4, 2020·Updated Dec 22, 2020

In Brief

A Phase 3 clinical trial evaluating Paracetamol injection and Ibuprofen injection, Paracetamol injection and normal saline, and 1 other intervention for Analgesia. Completed, enrolled 36 participants across 2 sites.

Detailed Summary

Adequate pain management has an important role in supporting early ambulation after the Total Knee Arthroplasty (TKA). Multimodal analgesia is one of the modalities of overcoming postoperative pain. The use of combination Paracetamol and Ibuprofen injection is expected to reduce total morphine consumption after TKA.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAnalgesia
CountriesIndonesia
Collaborators--

Timeline

Phase 3CompletedFinished
202120222023202420252026
First PostedJun 4, 2020
Enrollment StartJun 5, 2020
Primary CompletionNov 30, 2020
Study CompletionDec 15, 2020
TodayJul 2, 2026
Enrollment to primary: 6 monthsPosted 6.1 years ago

Interventions

Paracetamol injection and Ibuprofen injectiondrug

Use of combination acetaminophen and ibuprofen to reduce morphine requirement inpatient after Total knee arthroplasty

Paracetamol injection and normal salinedrug

Use of paracetamol and normal saline to reduce morphine requirement inpatient after Total knee arthroplasty

Ibuprofen Injection and normal salinedrug

Use of ibuprofen and normal saline to reduce morphine requirement inpatient after Total knee arthroplasty