CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 184 enrolled
Drug / intervention
Varenicline +2 moredrug
Likely dose
Varenicline 0.5 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04445662
NCT04445662N/ACompleted

Financial Incentives for Homeless Smokers: A Community-based RCT

Massachusetts General Hospital·interventional·Posted Jun 24, 2020·Updated Oct 21, 2025

In Brief

A clinical study evaluating Financial incentives, Varenicline, and 1 other intervention for Tobacco Smoking. Completed, enrolled 184 participants across 1 site.

Detailed Summary

This community-based randomized controlled trial will test the effect of contingent financial rewards on smoking abstinence among homeless-experienced adult cigarette smokers. Participants will be recruited from 3 Boston Health Care for the Homeless Program locations: a shelter clinic, a day center clinic, and a medical center clinic. All participants will be offered a varenicline prescription and tobacco coaching. Incentive arm participants will receive escalating financial rewards for saliva cotinine levels \<30 ng/ml, assessed 10 times over 12 weeks. Embedded qualitative interviews will explore the mechanisms of on-treatment and post-treatment effects of financial incentives on smoking abstinence in the context of homelessness.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTobacco Smoking
CountriesUnited States

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedJun 24, 2020
Enrollment StartJun 10, 2021
Primary CompletionAug 1, 2024
Study CompletionOct 24, 2024
TodayJul 2, 2026
Enrollment to primary: 3.1 yearsPosted 6.0 years ago

Interventions

Financial incentivesbehavioral

Escalating financial rewards for saliva cotinine levels \<30 ng/mL, assessed 10 times over 12 weeks

Vareniclinedrug

* Day 1 - 3: 0.5 mg daily * Day 4 - 7: 0.5 mg twice daily * Day 8 - Week 12: 1 mg twice daily * Dose/schedule may be adjusted based on medical history and clinician judgement

Tobacco coachingbehavioral

5 one-on-one tobacco cessation coaching sessions over 12 weeks