CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 826 enrolled
Drug / intervention
Reveal LINQ™ Insertable Cardiac Monitor with investigational ALLEVIATE-HF RAMware download +1 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04452149
NCT04452149N/ACompleted

Algorithm Using LINQ Sensors for Evaluation And Treatment of Heart Failure

Medtronic Cardiac Rhythm and Heart Failure·interventional·Posted Jun 30, 2020·Updated Jan 13, 2026

In Brief

A clinical study evaluating Reveal LINQ™ Insertable Cardiac Monitor with investigational ALLEVIATE-HF RAMware download and Medication intervention for Heart Failure NYHA Class II and Heart Failure NYHA Class III. Completed, enrolled 826 participants across 53 sites.

Detailed Summary

The ALLEVIATE-HF study is a prospective, randomized, controlled, blinded, multi-site, interventional, investigational device exemption (IDE) pivotal study. The purpose of the study is to demonstrate the safety and efficacy of a patient management pathway that utilizes an integrated device diagnostic-based risk stratification algorithm to guide patient care in subjects with NYHA class II and III heart failure, and to demonstrate the safety of the Reveal LINQ™ system and procedure in the study population.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedJun 30, 2020
Enrollment StartSep 3, 2020
Primary CompletionJun 2, 2025
TodayJul 2, 2026
Enrollment to primary: 4.7 yearsPosted 6.0 years ago

Interventions

Reveal LINQ™ Insertable Cardiac Monitor with investigational ALLEVIATE-HF RAMware downloaddevice

Reveal LINQ™ Insertable Cardiac Monitor with investigational ALLEVIATE-HF RAMware download.

Medication interventionother

Risk status guided medication intervention.