CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 87 enrolled
Drug / intervention
ZW25 (Zanidatamab)drug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04466891
NCT04466891Phase 2Completed

A Phase 2b, Open-label, Single-arm Study of ZW25 Monotherapy in Subjects With Advanced or Metastatic HER2-amplified Biliary Tract Cancers

Jazz Pharmaceuticals·interventional·Posted Jul 10, 2020·Updated Sep 15, 2025

In Brief

A Phase 2 clinical trial evaluating ZW25 (Zanidatamab) for HER2-amplified Biliary Tract Cancers. Completed, enrolled 87 participants across 67 sites in 9 countries.

Detailed Summary

This multicenter, open-label, single-arm trial will evaluate the anti-tumor activity of ZW25 (zanidatamab) monotherapy in subjects with human epidermal growth factor receptor 2 (HER2)-amplified, inoperable and advanced or metastatic biliary tract cancer (BTC), including intra-hepatic cholangiocarcinoma (ICC), extra-hepatic cholangiocarcinoma (ECC), and gallbladder cancer (GBC).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesCanada, Chile, China, France, Italy, South Korea, Spain, United Kingdom, United States

Timeline

Phase 2CompletedFinished
202120222023202420252026
First PostedJul 10, 2020
Enrollment StartOct 1, 2020
Primary CompletionJul 28, 2023
Study CompletionJul 11, 2024
TodayJul 2, 2026
Enrollment to primary: 2.8 yearsPosted 6.0 years ago

Interventions

ZW25 (Zanidatamab)drug

Administered intravenously