At a glance
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Influence of Patient Sex on Pain Control and Multimodal Analgesia in Total Knee Arthroplasty
In Brief
A clinical study evaluating Multimodal analgesia including pregabalin and Multimodal analgesia not including pregabalin for Knee Osteoarthritis and Pain, Postoperative. Completed, enrolled 250 participants across 1 site.
Detailed Summary
The purpose of this study is to examine the influence of sex on postoperative pain, following total knee arthroplasty (TKA). Patients will first be stratified by sex and then be randomized into one of two multimodal analgesic regimen (MAR), which differ in presence of pregabalin. We hypothesize that that acute postoperative pain scores are different over time between males and females and between multimodal analgesic regimens following TKA. Investigators will be blinded to which multimodal group patients are in. Patients will complete surveys in the office, during their hospital stay, and at followup intervals for up to six months.
Study Details
Timeline
Interventions
Standardized protocol for our institution with multiple medications used for pain (NSAIDs, opioids, dexamethasone) and non-narcotic spinal. Patient will be provided with an preoperative pregabalin dose and will continue medication two weeks postoperatively.
Standardized protocol for our institution with multiple medications used for pain (NSAIDs, opioids, dexamethasone) and non-narcotic spinal.