CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 121 enrolled
Drug / intervention
PLN-74809 +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04480840
NCT04480840Phase 2Completed

A Randomized, Double-blind, Dose-ranging, Placebo-controlled, Phase 2a Evaluation of the Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Participants With Primary Sclerosing Cholangitis (PSC) and Suspected Liver Fibrosis (INTEGRIS-PSC)

Pliant Therapeutics, Inc.·interventional·Posted Jul 21, 2020·Updated Jan 23, 2026

In Brief

A Phase 2 clinical trial evaluating PLN-74809 and Placebo for Primary Sclerosing Cholangitis. Completed, enrolled 121 participants across 60 sites in 9 countries.

Detailed Summary

A Phase 2a, multicenter, randomized, double-blind, dose-ranging, placebo-controlled, study to evaluate the safety, tolerability, and PK of PLN-74809 in participants with primary sclerosing cholangitis and suspected liver fibrosis

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustralia, Austria, Belgium, Canada, France, Germany, Netherlands, United Kingdom, United States
Collaborators--

Timeline

Phase 2CompletedFinished
202120222023202420252026
First PostedJul 21, 2020
Enrollment StartJul 27, 2020
Primary CompletionFeb 26, 2024
Study CompletionMar 18, 2024
TodayJul 2, 2026
Enrollment to primary: 3.6 yearsPosted 5.9 years ago

Interventions

PLN-74809drug

PLN-74809

Placebodrug

Placebo