CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 60 enrolled
Drug / intervention
Comprehensive Doppler Ultrasound of the Placenta +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04506970
NCT04506970N/ACompleted
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Predicting Placental Pathologies by Ultrasound Imaging of the Human Placenta During Gestation

Mayo Clinic·observational·Posted Aug 10, 2020·Updated Oct 10, 2024

In Brief

An observational study evaluating Comprehensive Doppler Ultrasound of the Placenta and Verasonics Ultrasound scanner (ultra-sensitive Doppler imaging) for Intrauterine Growth Restriction and 2 related conditions. Completed, enrolled 60 participants across 1 site.

Detailed Summary

Intrauterine growth restriction (IUGR) is caused when the placenta cannot provide enough nutrients to allow normal growth of the fetus during pregnancy. It is unclear why IUGR happens, but an increase in inflammatory T cells in the placenta known as villitis of unknown etiology (VUE) is observed in many IUGR infants. The investigators aim to develop ultrasound methods for diagnosing VUE to understand it's role in IUGR.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsIntrauterine Growth Restriction, Villitis, IUGR
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedAug 10, 2020
Enrollment StartSep 27, 2020
Primary CompletionJul 31, 2023
Study CompletionOct 31, 2023
TodayJul 2, 2026
Enrollment to primary: 2.8 yearsPosted 5.9 years ago

Interventions

Comprehensive Doppler Ultrasound of the Placentaother

Ultrasound measures to be collected include uterine artery (UtA) and umbilical artery (UA), systolic/diastolic (S/D) ratio, resistance index (RI), pulsatility index (PI) and presence of early diastolic notch.

Verasonics Ultrasound scanner (ultra-sensitive Doppler imaging)other

In addition, a Verasonics ultrasound scanner will be used for ultra-sensitive Doppler imaging. Data will be collected on vessel density, periphery-to-center vessel density ratio (VDR) and microvessel morphology.